Queen of Heaven provides a strong high school preparatory education for its students. It follows the Common Core prescribed by the New York State Education Department and the Diocese of Buffalo. In addition to the core subjects of religion, reading, English language arts, mathematics, science, and social studies, students receive instruction in art, music, computer technology, library, Spanish and physical education. New York State assessments are administered in grades 4, 5 and 8. Standardized tests are given to students in grades 2, 3, 5, 6 and 7 each year.
Religion is taught each day to all grade levels. Each Thursday morning, the school community gathers for Mass. Service projects are an integral part of school life as well as religious experiences such as prayer services and various devotional practices.